News
- 2025-08-29
Nature Medicine Publishes a Breakthrough! Experts highly praise
A major step forward for off-the-shelf cell therapy in autoimmunity. Prof. Huji Xu, Prof. Xin Lin, and BriSTAR Immunotech are breaking new ground with YTS109, a hypoimmune allogeneic T cell product. Published in Nature Medicine:
- 2025-08-28
Landmark Study Published in Nature Medicine: BriSTAR Immunotech’s Allogeneic STAR-T Breaks New Ground in Refractory Lupus Nephritis Treatment
On August 27, 2025, a groundbreaking study by BriSTAR Immunotech in collaboration with the team led by Professor Huji Xu and Professor Xin Lin , was published in the top international journal Nature Medicine (Impact Factor: 58.7).
- 2024-11-18
Professor Lin Xin's Team Publishes Landmark Research in Cell Sub-Journal: STAR-T Technology Enables Targeting of Intracellular Neoantigens for Solid Tumor Therapy
Recently, a team led by Professor Xin Lin — Scientific Founder of Bristar Immunotech and Tenured Professor at Tsinghua University — published a research article titled "TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens" in Cell Reports, a sub-journal of Cell. This study demonstrates the high sensitivity of the novel chimeric antigen receptor STAR-T in targeting tumors with low-abundance neoantigens, promising to advance T-cell immunotherapy into an era of greater precision and efficacy. It also marks another breakthrough in STAR-T technology research.
About us
Our team at BriSTAR Immunotech is dedicated to the development and commercialization of innovative T cell immunotherapy products for the treatment of cancer and viral infections with urgent unmet medical needs.
We leverage our proprietary STAR-T platform to engineer next-generation T cell therapies for treating hematological malignancies and solid tumors. The STAR-T platform combines the advantages of CAR-T (Chimeric Antigen Receptor T-Cell immunotherapy) and TCR-T (T Cell Receptor T-cell immunotherapy) to produce mono- or bi-specific T cell therapies.
The promising antitumor actions of STAR-T cell therapies include better antigen sensitivity and stronger tumor infiltration. These properties are critical for achieving better responses in cancer patients, especially in treating solid tumors.

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2018
Established In
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60+
Employees
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2000m²
37,600 sq.ft. R&D center
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8+
Important Publications
Platform


Technology
Manufacturing
Pioneering Technology Platform
STAR-T & enTCR-T


Technology
Pioneering Technology Platform
STAR-T & enTCR-T
Manufacturing

Pipeline
Our product pipeline is designed to address urgent unmet clinical needs in hematologic malignancies and solid tumors.
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